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When a affected person now not requires therapy with oxycodone, it may be highly recommended to taper the dose slowly to prevent signs or symptoms of withdrawal. In absence of adequate discomfort Management, the potential for hyperalgesia, tolerance and development of fundamental disease really should be regarded (see segment 4.4).Ritonavir or lopi

Behavioral sensitization consisted of two phases: enhancement and expression. For development of behavioral sensitization 6 injections of copyright (15 mg/kg intraperitoneally (i.p.)) or saline ended up administered each next working day. Expression of behavioral sensitization was calculated thirty times once the past injection (withdrawal day 30